Three of the four playable characters in the main campaign are women, as is the primary antagonist. It's notable that Capcom has built a really fun, dumb action storyline almost entirely around women. The narrative jumps back and forth between those two exploring and a second story thread six months later as Barry comes to the island to find Moira. In the opening scenes Barry's daughter, Moira, is kidnapped alongside Claire, and the duo are imprisoned on a mysterious island. Resident Evil Revelations 2 follows two classic characters from the series' past: Claire Redfield and Barry Burton.
